[CAS NO. 219989-84-1] Ixabepilone (BMS-247550)

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PRODUCTS SPECIFICATIONS [219989-84-1]

Catalog

SLK-S7930

Brand

Selleck

CAS

219989-84-1

DESCRIPTION [219989-84-1]

Overview

MDL	MFCD04307791
Molecular Weight	506.70
Molecular Formula	C27H42N2O5S
SMILES	C[C@@]12[C@@](O1)(C[C@@H](\C(=C\C=3N=C(C)SC3)\C)NC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC2)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9736 mL	9.8678 mL	19.7355 mL
5 mM	0.3947 mL	1.9736 mL	3.9471 mL
10 mM	0.1974 mL	0.9868 mL	1.9736 mL
50 mM	0.0395 mL	0.1974 mL	0.3947 mL

Description

Ixabepilone (Azaepothilone B, BMS-247550, Ixempra, Aza-epothilone B) is an orally bioavailable inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.

Targets

microtubule(tubulin stabilising) ^[1]

In vitro

BMS-247550 is a highly potent cytotoxic agent capable of killing cancer cells at low nanomolar concentrations and retains its antineoplastic activity against human cancers that are naturally insensitive to paclitaxel or that have developed resistance to paclitaxel.

References

[1] Lee FY, et al. Clin Cancer Res. 2001, 7(5):1429-1437.

Synonyms

17-Oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)-

(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione

BMS 247550

Azaepothilone B

BMS 247550-1

Ixabepilone

Ixempra