[CAS NO. 927822-86-4] KC7F2
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PRODUCTS SPECIFICATIONS [927822-86-4]
Catalog
SLK-S7946
Brand
Selleck
CAS
927822-86-4
DESCRIPTION [927822-86-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 570.38 |
| Molecular Formula | C16H16Cl4N2O4S4 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7532 mL | 8.7661 mL | 17.5322 mL |
| 5 mM | 0.3506 mL | 1.7532 mL | 3.5064 mL |
| 10 mM | 0.1753 mL | 0.8766 mL | 1.7532 mL |
| 50 mM | 0.0351 mL | 0.1753 mL | 0.3506 mL |
Description
KC7F2 is a selective translation inhibitor with of 20 μM in a cell-based assay.
Targets
| HIF-1α [1] |
| 20 μM |
In vitro
KC7F2 inhibits HIF-1α protein synthesis but not its mRNA transcription. KC7F2 inhibits HRE-driven transcription and decreases HIF-1α protein levels in LN229-HRE-AP cells. KC7F2 shows a dose-response cytotoxicity with IC50 of approximately 15 to 25 μM in cancer cells MCF7, LNZ308, A549, U251MG, and LN229. In D54MG glioma cells, KC7F2 inhibits colony formation, especially under hypoxia. In hypoxic microglial cultures, KC7F2 downregulates the expression of TfR and DMT, and reduces the HIF-1α mediated iron accumulation.
References
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