[CAS NO. 1246086-78-1] VU 0364439
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PRODUCTS SPECIFICATIONS [1246086-78-1]
Catalog
SLK-S8035
Brand
Selleck
CAS
1246086-78-1
DESCRIPTION [1246086-78-1]
Overview
| MDL | MFCD22378484 |
|---|---|
| Molecular Weight | 422.29 |
| Molecular Formula | C18H13Cl2N3O3S |
| SMILES | O=C(NC1=CC=C(S(=O)(NC2=CC=CC=C2Cl)=O)C(Cl)=C1)C3=NC=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3680 mL | 11.8402 mL | 23.6804 mL |
| 5 mM | 0.4736 mL | 2.3680 mL | 4.7361 mL |
| 10 mM | 0.2368 mL | 1.1840 mL | 2.3680 mL |
| 50 mM | 0.0474 mL | 0.2368 mL | 0.4736 mL |
Description
VU 0364439 is a positive allosteric modulator (PAM), with of 19.8 nM.
Features
The most potent mGlu4 PAM reported to date.
Targets
| mGluR4 [1] |
| 19.8 nM(EC50) |
In vivo
VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
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