[CAS NO. 115104-28-4] MK571

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [115104-28-4]

Catalog

SLK-S8126

Brand

Selleck

CAS

115104-28-4

DESCRIPTION [115104-28-4]

Overview

MDL	-
Molecular Weight	515.09
Molecular Formula	C26H27ClN2O3S2
SMILES	C(=C/C1=CC(C(SCCC(N(C)C)=O)SCCC(O)=O)=CC=C1)\C2=NC3=C(C=C2)C=CC(Cl)=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9414 mL	9.7070 mL	19.4141 mL
5 mM	0.3883 mL	1.9414 mL	3.8828 mL
10 mM	0.1941 mL	0.9707 mL	1.9414 mL
50 mM	0.0388 mL	0.1941 mL	0.3883 mL

Description

MK571 (L660711) is a selective, orally active antagonist.

Targets

CysLT1 ^[1]

MRP1 ^[2]

MRP4 ^[2]

cMOAT ^[4]

In vitro

L-660,711 inhibited [3H]LTD4 binding in guinea pig lung with a Ki value of 0.22±0.15 nM (n=35) and [3H]LTD4 binding in human lung with a Ki value of 2.1±1.8 nM (n=29). L660,711 was essentially inactive versus [3H]LTC4 binding with IC50 values of 23±11 μM (n=16) and 32 μM (n=1) in guinea pig and human lung, respectively.

In vivo

MK-571 is well tolerated in healthy young men. After oral administration, MK-571 is rapidly absorbed. The maximum plasma concentration occurring at 1.1-1.5 h at all doses.

References

[1] Jones TR, et al. Can J Physiol Pharmacol. 1989, 67(1):17-28.
[2] Amanda Tivnan, et al. Front Neurosci. 2015, 9:218.
[3] Depré M, et al. Eur J Clin Pharmacol. 1992, 43(4):427-30.
[4] Luo FR, et al. Drug Metab Dispos. 2002, 30(7):763-70.

Synonyms

Propanoic acid, 3-[[[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-

Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-, (E)-

3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid

L 660711

MK 571