[CAS NO. 144875-48-9] Resiquimod (R-848)
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PRODUCTS SPECIFICATIONS [144875-48-9]
Store
Catalog
SLK-S8133
Brand
Selleck
CAS
144875-48-9
DESCRIPTION [144875-48-9]
Overview
| MDL | MFCD00937759 |
|---|---|
| Molecular Weight | 314.38 |
| Molecular Formula | C17H22N4O2 |
| SMILES | C(C(C)(C)O)N1C=2C=3C(N=C(N)C2N=C1COCC)=CC=CC3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent agonist that induces the upregulation of cytokines such as , and . Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2.
In vitro
Resiquimod activates immune cells and induces proliferation of wild-type splenocytes via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway. Resiquimod also modulates dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses. Resiquimod induces the differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells, and may improve cancer immunotherapy by reducing immunosuppressive MDSCs.
References
Synonyms
1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-(ethoxymethyl)-α,α-dimethyl-
4-Amino-2-(ethoxymethyl)-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol
S 28463
R 848
Resiquimod
1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
Resimiquimod
4-Amino-2-(ethoxymethyl)-1-(2-hydroxyisobutyl)imidazo[4,5-c]quinoline
1-[4-Amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
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