[CAS NO. 127373-66-4] Sivelestat (ONO-5046)

Name: Sivelestat (ONO-5046)
Brand: Arctom Scientific
SKU: SLK-S8136

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PRODUCTS SPECIFICATIONS [127373-66-4]

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Catalog

SLK-S8136

Brand

Selleck

CAS

127373-66-4

DESCRIPTION [127373-66-4]

Overview

MDL	MFCD00889071
Molecular Weight	434.46
Molecular Formula	C20H22N2O7S
SMILES	C(NCC(O)=O)(=O)C1=C(NS(=O)(=O)C2=CC=C(OC(C(C)(C)C)=O)C=C2)C=CC=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3017 mL	11.5085 mL	23.0171 mL
5 mM	0.4603 mL	2.3017 mL	4.6034 mL
10 mM	0.2302 mL	1.1509 mL	2.3017 mL
50 mM	0.0460 mL	0.2302 mL	0.4603 mL

Description

Sivelestat (ONO5046, LY544349, EI546) is a potent and selective inhibitor of with of 44nM. It almost shows no activity at a range of other proteases.

Targets

neutrophil elastase ^[1]

In vitro

sivelestat reduces the levels of inflammatory mediators by inhibiting NF-kB. It suppresses the growth of gastric cancer cells by inhibiting the release of TGF-α stimulated by NE; Sivelestat suppresses iNOS gene expression in proinflammatory cytokine-stimulated hepatocytes.

In vivo

sivelestat could attenuate sepsis-related kidney injury in rats. It blocks GAPDH/Siah1 which is a novel signaling pathway during the progression of spinal cord injury. Administration of sivelestat attenuates pulmonary fibrosis after acute lung injury in mice.

References

[1] Li G, et al. Int J Mol Med. 2016, 38(3):767-75.
[2] Wada Y, et al. Cancer Science. 2006, 97(10):1037-1043.
[3] Hagiwara S, et al. Inflamm Res. 2009, 58(4):198-203.
[4] Araki Y, et al. Dig Dis Sci. 2011, 56(6):1672-81.
[5] Huo J, et al. Neuroscience. 2016, 330:171-180.
[6] Fujino N, et al. Exp Lung Res. 2012, 38(1):28-36.

Synonyms

Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester

Glycine, N-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-

ONO 5046

EI 546

Sivelestat

LY 544349

2-(2-(4-(Pivaloyloxy)phenylsulfonamido)benzamido)acetic acid