[CAS NO. 1154028-82-6] Molidustat (BAY 85-3934)

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PRODUCTS SPECIFICATIONS [1154028-82-6]

Catalog

SLK-S8138

Brand

Selleck

CAS

1154028-82-6

DESCRIPTION [1154028-82-6]

Overview

MDL	-
Molecular Weight	314.30
Molecular Formula	C13H14N8O2
SMILES	O=C1N(NC=C1N2C=CN=N2)C=3C=C(N=CN3)N4CCOCC4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1817 mL	15.9084 mL	31.8167 mL
5 mM	0.6363 mL	3.1817 mL	6.3633 mL
10 mM	0.3182 mL	1.5908 mL	3.1817 mL
50 mM	-	-	-

Description

Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase () inhibitor with of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.

Targets

PHD2 ^[1] (Cell-free assay)	PHD3 ^[1] (Cell-free assay)	PHD1 ^[1] (Cell-free assay)
280 nM	450 nM	480 nM

In vitro

In vitro, Molidustat induces the transcription of hypoxia-sensitive genes in HeLa, A549, and Hep3B cells.

References

[1] Flamme I, et al. PLoS One. 2014, 9(11):e111838.
[2] Wing PAC, et al. Cell Rep. 2021 Apr 20;35(3):109020.

Synonyms

3H-Pyrazol-3-one, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-

1,2-Dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one

2-[6-(Morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one

Molidustat

BAY 85-3934

2-(6-Morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one