[CAS NO. 836620-48-5] AS1842856
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PRODUCTS SPECIFICATIONS [836620-48-5]
Catalog
SLK-S8222
Brand
Selleck
CAS
836620-48-5
DESCRIPTION [836620-48-5]
Overview
| MDL | MFCD30718173 |
|---|---|
| Molecular Weight | 347.38 |
| Molecular Formula | C18H22FN3O3 |
| SMILES | O=C(C1=CN(CC)C2=C(C(N)=C(F)C(NC3CCCCC3)=C2)C1=O)O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of with of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses .
Targets
| Foxo1 [1] (In HepG2 cells) |
| 33nM |
In vitro
AS1842856 predominantly suppresses Foxo1-mediated transactivation by directly binding to Foxo1. In HepG2 cells transiently transfected with a Foxo1 expression vector, AS1842856 potently represses Foxo1-mediated promoter activity in a dose-dependent manner similar to that seen in insulin treatment.AS1842856 administered at 0.1 μM inhibits Foxo3a- and Foxo4-mediated promoter activity by 3 and 20%, respectively. In contrast, Foxo1-mediated promoter activity is decreased by 70%. Foxo1 inhibitor AS1842856 may suppress endogenous G6Pase and PEPCK activities by decreasing their mRNA levels, which may lead to inhibition of glucose production in Fao cells.
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