[CAS NO. 1609402-14-3] HA15
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [1609402-14-3]
Catalog
SLK-S8299
Brand
Selleck
CAS
1609402-14-3
DESCRIPTION [1609402-14-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 466.58 |
| Molecular Formula | C23H22N4O3S2 |
| SMILES | CC(NC1=NC(C2=CC=CC(NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O)=C2)=CS1)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
HA15 is a molecule that targets specifically also known as or . HA15 displays activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
Targets
| BiP/GRP78/HSPA5 [1] |
In vitro
HA15 induces ER stress leading to cancer cell death in vitro and overcomes BRAF inhibitor resistance in melanoma cells.
In vivo
HA15 induces ER stress leading to cancer cell death and exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors.
Powered by Arctom Copyright © 2025 Arctom.
All rights reserved.