[CAS NO. 214358-33-5] 1400W 2HCl
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PRODUCTS SPECIFICATIONS [214358-33-5]
Catalog
SLK-S8337
Brand
Selleck
CAS
214358-33-5
DESCRIPTION [214358-33-5]
Overview
| MDL | MFCD03428622 |
|---|---|
| Molecular Weight | 250.17 |
| Molecular Formula | C10H15N3.2HCl |
| SMILES | CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9973 mL | 19.9864 mL | 39.9728 mL |
| 5 mM | 0.7995 mL | 3.9973 mL | 7.9946 mL |
| 10 mM | 0.3997 mL | 1.9986 mL | 3.9973 mL |
| 50 mM | 0.0799 mL | 0.3997 mL | 0.7995 mL |
Description
1400W (N-(3-(Aminomethyl)benzyl)acetamidine) is a slow, tight binding, and highly selective inhibitor of .
Targets
In vitro
1400W is either an irreversible inhibitor or an extremely slowly reversible inhibitor of human iNOS. Inhibition of human iNOS by 1400W is time-dependent. 1400W is competitive with L-arginine. 1400W is not a substrate for iNOS.
In vivo
1400W selectively prevents microvasculature injury in rats. 1400W is greater than 50-fold more potent against iNOS than eNOS in a rat model of endotoxin-induced vascular injury. Moreover, 1400W also dose-dependently reduces LPS-induced vascular leakage associated with iNOS induction in the colon, lung, liver, kidney, and heart. The maximal protection is close to 100% for all organs except the kidney (kidney:54%). 1400W has an ameliorative effect on both oxidative and nitrosative stress in the kidneys against renal I/R injury in rats. Treatment with 1400W can reduce the rate of growth of solid tumors in mice.
References
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