[CAS NO. 1639042-08-2] AZD9496
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PRODUCTS SPECIFICATIONS [1639042-08-2]
Catalog
SLK-S8372
Brand
Selleck
CAS
1639042-08-2
DESCRIPTION [1639042-08-2]
Overview
| MDL | MFCD28902195 |
|---|---|
| Molecular Weight | 442.47 |
| Molecular Formula | C25H25F3N2O2 |
| SMILES | O=C(O)/C=C/C1=CC(F)=C([C@H]2N(CC(C)(F)C)[C@H](C)CC3=C2NC4=C3C=CC=C4)C(F)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2600 mL | 11.3002 mL | 22.6004 mL |
| 5 mM | 0.4520 mL | 2.2600 mL | 4.5201 mL |
| 10 mM | 0.2260 mL | 1.1300 mL | 2.2600 mL |
| 50 mM | 0.0452 mL | 0.2260 mL | 0.4520 mL |
Description
AZD9496 is an oral inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.
Targets
| estrogen receptor [1] |
In vitro
AZD9496 showed pmol/L equipotent binding to both ERα and ERβ isoforms. AZD9496 directly targets ERα for downregulation in vitro. And it also antagonizes and downregulates mutant ER in vitro and in vivo. The IC50s of ERα binding, ERα downregulation, ERα antagonism for AZD9496 are 0.82, 0.14 and 0.28 nM, respectively.
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