[CAS NO. 2097381-85-4] VH298
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PRODUCTS SPECIFICATIONS [2097381-85-4]
Catalog
SLK-S8449
Brand
Selleck
CAS
2097381-85-4
DESCRIPTION [2097381-85-4]
Overview
| MDL | MFCD30742947 |
|---|---|
| Molecular Weight | 523.65 |
| Molecular Formula | C27H33N5O4S |
| SMILES | O=C([C@H]1N(C([C@@H](NC(C2(C#N)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
VH298 is a potent inhibitor that stabilizes . VH298 blocks the VHL:HIF-α interaction with Kd of 90 nM in isothermal titration calorimetry (ITC) and 80 nM in a competitive fluorescence polarization assay. VH-298 can be used in PROTAC technology.
Targets
In vitro
VH298 can activate the HIF-1 signalling pathway by stabilizing both forms of HIF-1α in vitro. VH298 promotes rFb variability, migration, and synthesis of collagen and regulatory cell factors. VH298 improves the angiogenesis of hUVEC.
References
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