[CAS NO. 664969-54-4] LF3
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PRODUCTS SPECIFICATIONS [664969-54-4]
Catalog
SLK-S8474
Brand
Selleck
CAS
664969-54-4
DESCRIPTION [664969-54-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 416.56 |
| Molecular Formula | C20H24N4O2S2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4006 mL | 12.0031 mL | 24.0061 mL |
| 5 mM | 0.4801 mL | 2.4006 mL | 4.8012 mL |
| 10 mM | 0.2401 mL | 1.2003 mL | 2.4006 mL |
| 50 mM | 0.0480 mL | 0.2401 mL | 0.4801 mL |
Description
LF3 is a specific inhibitor of canonical signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.
Targets
| β-catenin/Tcf4 [1] (Cell-free assay) |
| 1.65 μM |
In vitro
LF3 does not cause cell death or interfere with cadherin-mediated cell-cell adhesion. The self-renewal capacity of cancer stem cells is blocked by LF3 in concentration-dependent manners, as examined by sphere formation of colon and head and neck cancer stem cells under nonadherent conditions. LF3 inhibits Wnt/β-catenin signaling, but does not interfere with E-cadherin/β-catenin-mediated cell-cell adhesion. LF3 blocks the expression of a series of Wnt target genes in Wnt-addicted colon cancer cells. It inhibits proliferation of Wnt-addicted colon cancer cells through induction of cell-cycle arrest and also inhibits self-renewal capacity of CSCs.
In vivo
LF3 reduces tumor growth and induces differentiation in a mouse xenograft model of colon cancer while exhibiting no significant toxicity for mice and does not disturb the normal histology of the gut of mice.
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