[CAS NO. 1616287-82-1] PF-06726304
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [1616287-82-1]
Catalog
SLK-S8494
Brand
Selleck
CAS
1616287-82-1
DESCRIPTION [1616287-82-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 446.33 |
| Molecular Formula | C22H21Cl2N3O3 |
| SMILES | O=C1N(CC2=C(C)C=C(C)NC2=O)CCC3=C1C(Cl)=C(C4=C(C)ON=C4C)C=C3Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2405 mL | 11.2025 mL | 22.4049 mL |
| 5 mM | 0.4481 mL | 2.2405 mL | 4.4810 mL |
| 10 mM | 0.2240 mL | 1.1202 mL | 2.2405 mL |
| 50 mM | - | - | - |
Description
PF-06726304 is a selective inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits with the IC50 value of 15 nM.
In vitro
PF-06726304 displays very potent EZH2 biochemical inhibition as well as good activity in the cell H3K27Me3 reduction and antiproliferation effect.
In vivo
PF-06726304 displays robust in vivo antitumor growth activity and dose-dependent de-repression of EZH2 target genes. PF-06726304 displays good efficacy in a diffuse large B-cell lymphoma Karpas-422 tumor model and exhibited on-target pharmacodynamic effects in vivo.
Powered by Arctom Copyright © 2025 Arctom.
All rights reserved.