[CAS NO. 1353563-85-5] AUNP-12

Name: AUNP-12
Brand: Arctom Scientific
SKU: SLK-S8549

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PRODUCTS SPECIFICATIONS [1353563-85-5]

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Catalog

SLK-S8549

Brand

Selleck

CAS

1353563-85-5

DESCRIPTION [1353563-85-5]

Overview

MDL	-
Molecular Weight	3261.55
Molecular Formula	C142H226N40O48
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	0.3066 mL	1.5330 mL	3.0660 mL
5 mM	0.0613 mL	0.3066 mL	0.6132 mL
10 mM	0.0307 mL	0.1533 mL	0.3066 mL
50 mM	-	-	-

Description

AUNP-12 (Aur-012, Aurigene-012, Aurigene NP-12), a new immune checkpoint modulator, is an inhibitor of the pathway.

Targets

PD-L1 ^[1]
(Cell-free assay)

In vitro

AUNP-12 displays an EC50 = 0.72 nM in the inhibition of binding PD1 to PD-L2 using hPDL2 expressing HEK293 cells, and an EC50 = 0.41 nM in a rat peripheral blood mononuclear cells (PBMC) proliferation assay using hPDL1 expressing MDA-MB231 cells.

References

[1] Sasikumar Pottayil G N, et al. patent: US 2011/0318373 A1.
[2] Musielak B, et al. Molecules. 2019 Aug 1;24(15):2804.