[CAS NO. 1423821-88-8] Tat-beclin 1 (Tat-BECN1)
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PRODUCTS SPECIFICATIONS [1423821-88-8]
Catalog
SLK-S8595
Brand
Selleck
CAS
1423821-88-8
DESCRIPTION [1423821-88-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 3741.1 |
| Molecular Formula | C164H251N57O45 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.2673 mL | 1.3365 mL | 2.6730 mL |
| 5 mM | 0.0535 mL | 0.2673 mL | 0.5346 mL |
| 10 mM | 0.0267 mL | 0.1337 mL | 0.2673 mL |
| 50 mM | - | - | - |
Description
Tat-beclin 1 (Tat-BECN1), a peptide known to stimulate through mobilization of endogenous , induces autophagy in vitro and in vivo and improves clinical outcomes.
In vitro
Tat-beclin 1 is a cell-permeable peptide that induces autophagy. Treatment with Tat-beclin 1, but not Tat-scrambled, results in a dose-dependent decrease in amounts of p62, a selective autophagy substrate, and a dose-dependent conversion of the non-lipidated form of LC3, LC3-I, to the lipidated, autophagosome-associated form of LC3, LC3-II, in multiple cell lines and primary murine embryonic fibroblasts (MEFs). Tat-beclin 1 markedly inhibits HIV-1 replication in primary human monocyte-derived macrophages.
In vivo
Tat-beclin 1 can induce autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice. Daily Tat-beclin 1 peptide treatment is well-tolerated in both neonatal and adult mice. Tat-beclin 1 peptide improves the clinical outcome of mice with CNS WNV(West Nile virus) infection.
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