[CAS NO. 1916571-90-8] NCT-503
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [1916571-90-8]
Store
Catalog
SLK-S8619
Brand
Selleck
CAS
1916571-90-8
DESCRIPTION [1916571-90-8]
Overview
| MDL | MFCD30343875 |
|---|---|
| Molecular Weight | 408.48 |
| Molecular Formula | C20H23F3N4S |
| SMILES | S=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2)CC1)NC3=NC(C)=CC(C)=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4481 mL | 12.2405 mL | 24.4810 mL |
| 5 mM | 0.4896 mL | 2.4481 mL | 4.8962 mL |
| 10 mM | 0.2448 mL | 1.2241 mL | 2.4481 mL |
| 50 mM | 0.0490 mL | 0.2448 mL | 0.4896 mL |
Description
NCT-503 is a inhibitor with the IC50 value of 2.5 μM. It is inactive against a panel of other dehydrogenases and shows minimal cross-reactivity in a panel of 168 GPCRs.
Targets
| PHGDH [1] (Cell-free) |
| 2.5 μM |
In vitro
NCT-503 has reasonable aqueous solubility, and exhibits favorable absorption, distribution, metabolism and excretion (ADME) properties.NCT-503 selectively blocks glucose-derived serine synthesis but at the same time triggers SHMT1-dependent one-carbon unit wasting to synthesize serine from glycine. This futile cycle depletes the cell of nucleotides and leads to cell cycle arrest.
References
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.