[CAS NO. 144707-18-6] 2-D08
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PRODUCTS SPECIFICATIONS [144707-18-6]
Catalog
SLK-S8696
Brand
Selleck
CAS
144707-18-6
DESCRIPTION [144707-18-6]
Overview
| MDL | MFCD27995567 |
|---|---|
| Molecular Weight | 270.24 |
| Molecular Formula | C15H10O5 |
| SMILES | O=C1C=C(C2=CC=C(O)C(O)=C2O)OC3=C1C=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7004 mL | 18.5021 mL | 37.0041 mL |
| 5 mM | 0.7401 mL | 3.7004 mL | 7.4008 mL |
| 10 mM | 0.3700 mL | 1.8502 mL | 3.7004 mL |
| 50 mM | 0.0740 mL | 0.3700 mL | 0.7401 mL |
Description
2-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of .
Targets
In vitro
2-D08, a inhibitor of protein SUMOylation, enhances the all-trans retinoic acid (ATRA)-induced expression of key genes involved in differentiation, proliferation, and apoptosis in non-APL AML cells. 2-D08 inhibits sumoylation by preventing transfer of SUMO from the UBC9-SUMO thioester to the substrate.
References
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