[CAS NO. 677331-12-3] iCRT14

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [677331-12-3]

Catalog

SLK-S8704

Brand

Selleck

CAS

677331-12-3

DESCRIPTION [677331-12-3]

Overview

MDL	MFCD04366833
Molecular Weight	375.44
Molecular Formula	C21H17N3O2S
SMILES	O=C(N(C1=CC=CC=C1)C/2=O)SC2=C\C3=C(C)N(C4=CC=CN=C4)C(C)=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.6635 mL	13.3177 mL	26.6354 mL
5 mM	0.5327 mL	2.6635 mL	5.3271 mL
10 mM	0.2664 mL	1.3318 mL	2.6635 mL
50 mM	0.0533 mL	0.2664 mL	0.5327 mL

Description

iCRT14 is a inhibitor with a Ki value of 54 ± 5.2 μM in homogeneous fluorescence polarization (FP) assay.

Targets

β-catenin/Tcf ^[1]

54 μM(Ki)

In vitro

iCRT14 suppresses the transcriptional activity of canonical Wnt signaling, downregulates Wnt/β-catenin-induced target genes, and inhibits the growth of colorectal cancer cells in vitro. iCRT14 shows a modest reduction in the amount of Dvl but has no effect on Dvl phosphorylation itself. iCRT14 inhibits the Wnt responsive STF16-luc reporter in mammalian HEK293 cells with an IC50 of 40.3 nM. iCRT14 can also interfere with TCF binding to DNA in addition to its ability to influence TCF-β-catenin interaction.

References

[1] Catrow JL, et al. J Med Chem. 2015, 58(11):4678-92.
[2] Gonsalves FC, et al. Proc Natl Acad Sci U S A. 2011, 108(15):5954-63.