[CAS NO. 1370046-40-4] SSE15206
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PRODUCTS SPECIFICATIONS [1370046-40-4]
Catalog
SLK-S8789
Brand
Selleck
CAS
1370046-40-4
DESCRIPTION [1370046-40-4]
Overview
| MDL | MFCD31746881 |
|---|---|
| Molecular Weight | 371.45 |
| Molecular Formula | C19H21N3O3S |
| SMILES | COC1=C(OC)C(OC)=CC(C2CC(C3=CC=CC=C3)=NN2C(N)=S)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
SSE15206 is a inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
Targets
| tubulin polymerization [1] |
In vitro
Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. Prolonged treatment of cells with SSE15206 results in apoptotic cell death accompanied by p53 induction.
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