[CAS NO. 1181770-72-8] EMD638683
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PRODUCTS SPECIFICATIONS [1181770-72-8]
Catalog
SLK-S8824
Brand
Selleck
CAS
1181770-72-8
DESCRIPTION [1181770-72-8]
Overview
| MDL | MFCD25541743 |
|---|---|
| Molecular Weight | 364.34 |
| Molecular Formula | C18H18F2N2O4 |
| SMILES | CC1=C(CC)C(C(NNC(C(O)C2=CC(F)=CC(F)=C2)=O)=O)=CC=C1O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7447 mL | 13.7234 mL | 27.4469 mL |
| 5 mM | 0.5489 mL | 2.7447 mL | 5.4894 mL |
| 10 mM | 0.2745 mL | 1.3723 mL | 2.7447 mL |
| 50 mM | 0.0549 mL | 0.2745 mL | 0.5489 mL |
Description
EMD638683 is a highly selective inhibitor of with IC50 of 3 μM. EMD638683 exhibits antihypertensive potency and anti-tumor activity.
Targets
| SGK1 [1] (Cell-free assay) |
| 3 μM |
In vitro
In vitro testing discloses EMD638683 as a SGK1 inhibitor with an IC50 of 3 μM. EMD638683 treatment significantly augments the radiation‑induced decrease of forward scatter, increase of phosphatidylserine exposure, decrease of mitochondrial potential, increase of caspase 3 activity, increase of DNA fragmentation and increase of late apoptosis.
References
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