[CAS NO. 2162982-11-6] BAY-218
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PRODUCTS SPECIFICATIONS [2162982-11-6]
Catalog
SLK-S8842
Brand
Selleck
CAS
2162982-11-6
DESCRIPTION [2162982-11-6]
Overview
| MDL | MFCD31736303 |
|---|---|
| Molecular Weight | 401.82 |
| Molecular Formula | C20H17ClFN3O3 |
| SMILES | O=C(C1=CC(C2=CC=C(Cl)C=C2)=NN(C3=CC=CC(F)=C3)C1=O)N[C@@H](C)CO |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4887 mL | 12.4434 mL | 24.8868 mL |
| 5 mM | 0.4977 mL | 2.4887 mL | 4.9774 mL |
| 10 mM | 0.2489 mL | 1.2443 mL | 2.4887 mL |
| 50 mM | 0.0498 mL | 0.2489 mL | 0.4977 mL |
Description
BAY-218 is a potent and selective small-molecule inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands.
Targets
| AhR [1] |
In vitro
Mechanistically, BAY-218 inhibits AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands. In vitro, BAY-218 rescues TNFα production from kynurenic acid(KA)-suppressed LPS-treated primary human monocytes.
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