[CAS NO. 1642288-47-8] Mavacamten (MYK-461)
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PRODUCTS SPECIFICATIONS [1642288-47-8]
Catalog
SLK-S8861
Brand
Selleck
CAS
1642288-47-8
DESCRIPTION [1642288-47-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 273.33 |
| Molecular Formula | C15H19N3O2 |
| SMILES | O=C1N(C(C)C)C(C=C(N[C@H](C2=CC=CC=C2)C)N1)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Mavacamten (MYK-461, SAR439152) is a small-molecule modulator of that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy (HCM), one of the most prevalent heritable cardiovascular disorders.
In vitro
MYK-461 primarily reduces the steady-state ATPase activity by inhibiting the rate of phosphate release of β-cardiac myosin-S1. MYK-461 modulates multiple steps of the myosin chemomechanical cycle. In addition to decreasing the rate-limiting step of the cycle (phosphate release), MYK-461 reduces the number of myosin-S1 heads that can interact with the actin thin filament during transition from the weakly to the strongly bound state without affecting the intrinsic rate. MYK-461 also decreases the rate of myosin binding to actin in the ADP-bound state and the ADP-release rate from myosin-S1 alone.
References
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