[CAS NO. 917389-32-3] Letermovir (AIC246)

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [917389-32-3]

Catalog

SLK-S8873

Brand

Selleck

CAS

917389-32-3

DESCRIPTION [917389-32-3]

Overview

MDL	MFCD22572725
Molecular Weight	572.55
Molecular Formula	C29H28F4N4O4
SMILES	C(C(O)=O)[C@@H]1N(C(=NC=2C1=CC=CC2F)N3CCN(CC3)C4=CC(OC)=CC=C4)C5=C(OC)C=CC(C(F)(F)F)=C5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.7466 mL	8.7329 mL	17.4657 mL
5 mM	0.3493 mL	1.7466 mL	3.4931 mL
10 mM	0.1747 mL	0.8733 mL	1.7466 mL
50 mM	0.0349 mL	0.1747 mL	0.3493 mL

Description

Letermovir (AIC246, MK-8228) is a novel compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.

In vitro

AIC246 blocks viral replication without inhibiting the synthesis of progeny HCMV DNA or viral proteins. It is one of the most potent anti-HCMV agents reported to date, with a cell culture EC50 in the one-digit nanomolar range (∼5 nM) and a selectivity index exceeding 15,000.

References

[1] Goldner T, et al. J Virol. 2011, 85(20):10884-93.
[2] Lischka P, et al. Antimicrob Agents Chemother. 2010, 54(3):1290-7.

Synonyms

4-Quinazolineacetic acid, 8-fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-, (4S)-

(4S)-8-Fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4-quinazolineacetic acid

AIC 246

Letermovir

Prevymis

(S)-2-(8-Fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid