[CAS NO. 1338934-59-0] MKC8866
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PRODUCTS SPECIFICATIONS [1338934-59-0]
Catalog
SLK-S8875
Brand
Selleck
CAS
1338934-59-0
DESCRIPTION [1338934-59-0]
Overview
| MDL | MFCD31540824 |
|---|---|
| Molecular Weight | 361.35 |
| Molecular Formula | C18H19NO7 |
| SMILES | O=CC1=C(C(C(C)=C2CC(N3CCOCC3)=O)=CC(OC)=C1O)OC2=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7674 mL | 13.8370 mL | 27.6740 mL |
| 5 mM | 0.5535 mL | 2.7674 mL | 5.5348 mL |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific inhibitor with IC50 of 0.29 μM for human IRE1α in vitro.
Targets
| hIRE1α [1] (Cell-free assay) |
| 0.29 μM |
In vitro
MKC8866 is optimized and refined from a family of IRE1α-specific endoribonuclease inhibitors obtained from a chemical library screen. MKC8866 effectively represses IRE1α-mediated XBP1 splicing in PCa cells and has favorable pharmacokinetic and pharmacodynamic properties.
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