[CAS NO. 2171386-10-8] RK-287107
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [2171386-10-8]
Store
Catalog
SLK-S8876
Brand
Selleck
CAS
2171386-10-8
DESCRIPTION [2171386-10-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 416.46 |
| Molecular Formula | C22H26F2N4O2 |
| SMILES | O=C1NC(N2CCC3(CC2)CN(CCO)C4=C3C(F)=CC(F)=C4)=NC5=C1CCCC5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4012 mL | 12.0060 mL | 24.0119 mL |
| 5 mM | 0.4802 mL | 2.4012 mL | 4.8024 mL |
| 10 mM | 0.2401 mL | 1.2006 mL | 2.4012 mL |
| 50 mM | 0.0480 mL | 0.2401 mL | 0.4802 mL |
Description
RK-287107 is a novel, potent and selective inhibitor with antitumor activity. RK-287107 inhibits and in vitro with IC50 of 14.3 nM and 10.6 nM.
In vitro
RK-287107 is a novel tankyrase-specific inhibitor that inhibits tankyrase-1 and -2. RK-287107 causes Axin2 accumulation and downregulates β-catenin, T-cell factor/lymphoid enhancer factor reporter activity and the target gene expression in colorectal cancer cells harboring the shortly truncated APC mutations. Consistently, RK-287107 inhibits the growth of APC-mutated (β-catenin-dependent) colorectal cancer COLO-320DM and SW403 cells but not the APC-wild (β-catenin-independent) colorectal cancer RKO cells.
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.