[CAS NO. 2225938-17-8] MS1943
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PRODUCTS SPECIFICATIONS [2225938-17-8]
Store
Catalog
SLK-S8918
Brand
Selleck
CAS
2225938-17-8
DESCRIPTION [2225938-17-8]
Overview
| MDL | MFCD32671554 |
|---|---|
| Molecular Weight | 718.93 |
| Molecular Formula | C42H54N8O3 |
| SMILES | O=C(NCC=1C(=O)NC(=CC1C)C)C2=CC(=CC3=C2C=NN3C(C)C)C=4C=NC(=CC4)N5CCN(CCNC(=O)CC67CC8CC(CC(C8)C6)C7)CC5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3910 mL | 6.9548 mL | 13.9096 mL |
| 5 mM | 0.2782 mL | 1.3910 mL | 2.7819 mL |
| 10 mM | 0.1391 mL | 0.6955 mL | 1.3910 mL |
| 50 mM | 0.0278 mL | 0.1391 mL | 0.2782 mL |
Description
MS1943 is an orally bioavailable selective degrader that effectively reduces EZH2 levels in cells with IC50 of 120 nM for inhibiting EZH2 methyltransferase activity.
Targets
| EZH2 [1] (Cell-free assay) |
| 120 nM |
In vitro
MS1943 is a first-in-class EZH2 selective degrader that effectively reduces EZH2 levels in cells. MS1943 has a profound cytotoxic effect in multiple TNBC cells, while sparing normal cells. MS1943 mediates its cytotoxic effects through ER stress and UPR induction in cells that are dependent for their growth on EZH2.
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