[CAS NO. 1887014-12-1] Olutasidenib (FT-2102)
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [1887014-12-1]
Store
Catalog
SLK-S8949
Brand
Selleck
CAS
1887014-12-1
DESCRIPTION [1887014-12-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 354.79 |
| Molecular Formula | C18H15ClN4O2 |
| SMILES | N#CC1=CC=C(N[C@H](C2=CC3=C(NC2=O)C=CC(Cl)=C3)C)C(N1C)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8186 mL | 14.0928 mL | 28.1857 mL |
| 5 mM | 0.5637 mL | 2.8186 mL | 5.6371 mL |
| 10 mM | 0.2819 mL | 1.4093 mL | 2.8186 mL |
| 50 mM | 0.0564 mL | 0.2819 mL | 0.5637 mL |
Description
Olutasidenib is a potent, orally bioavailable, brain penetrant and selective inhibitor with IC50 of 21.1 nM, 114 nM for , , respectively.
In vitro
Profiling in various mIDH1 over-expressing U87 cells and HCT116 cells reveals that olutasidenib potently inhibits 2-HG production by multiple IDH1-R132 mutants (R132H, R132C, R132G, R132L), suggesting olutasidenib could be efficacious against most IDH1-R132 mutant-expressing tumors. Olutasidenib is highly selective for IDH1 isoforms, showing no appreciable inhibition against wild-type IDH1 and IDH2 mutants..
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.