[CAS NO. 1415925-18-6] GSK2795039
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PRODUCTS SPECIFICATIONS [1415925-18-6]
Store
Catalog
SLK-S8974
Brand
Selleck
CAS
1415925-18-6
DESCRIPTION [1415925-18-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 450.56 |
| Molecular Formula | C23H26N6O2S |
| SMILES | O=S(C1=NN(C)C=C1)(NC2=C3C(N(C(C)C)C=C3C4=CC5=C(C=C4)CCN5C)=NC=C2)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2195 mL | 11.0973 mL | 22.1946 mL |
| 5 mM | 0.4439 mL | 2.2195 mL | 4.4389 mL |
| 10 mM | 0.2219 mL | 1.1097 mL | 2.2195 mL |
| 50 mM | 0.0444 mL | 0.2219 mL | 0.4439 mL |
Description
GSK2795039 is an inhibitor of with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits production, consumption and reduces .
In vitro
GSK2795039 inhibits both the formation of ROS and the utilization of the enzyme substrates, NADPH and oxygen, in a variety of semirecombinant cell-free and cell-based NOX2 assays. GSK2795039 inhibits NOX2 in an NADPH competitive manner and is selective over other NOX isoforms, xanthine oxidase, and endothelial nitric oxide synthase enzymes.
References
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