[CAS NO. 1951408-58-4] MAK683
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PRODUCTS SPECIFICATIONS [1951408-58-4]
Store
Catalog
SLK-S8983
Brand
Selleck
CAS
1951408-58-4
DESCRIPTION [1951408-58-4]
Overview
| MDL | MFCD31630846 |
|---|---|
| Molecular Weight | 376.39 |
| Molecular Formula | C20H17FN6O |
| SMILES | CC1=NC=CC=C1C2=CN=C(NCC3=C4CCOC4=CC=C3F)N5C2=NN=C5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6568 mL | 13.2841 mL | 26.5682 mL |
| 5 mM | 0.5314 mL | 2.6568 mL | 5.3136 mL |
| 10 mM | 0.2657 mL | 1.3284 mL | 2.6568 mL |
| 50 mM | - | - | - |
Description
MAK683 (EED inhibitor-1, example 2) is an inhibitor of . MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively.
Targets
In vitro
MAK-683 binds to EED and disrupts the PRC2 complex. Cell viability is not significantly affected and the levels of H3K27me3 are decreased. A significant increase in the percentage of mature PCs after MAK-683 treatment in association with a higher CD38 expression is also identified.
References
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