[CAS NO. 72581-71-6] Isosilybin

Name: Isosilybin
Brand: Arctom Scientific
SKU: SLK-S9250

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PRODUCTS SPECIFICATIONS [72581-71-6]

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Catalog

SLK-S9250

Brand

Selleck

CAS

72581-71-6

DESCRIPTION [72581-71-6]

Overview

MDL	MFCD09842608
Molecular Weight	482.44
Molecular Formula	C25H22O10
SMILES	C(O)C1C(OC=2C(O1)=CC(=CC2)[C@H]3OC=4C(C(=O)[C@@H]3O)=C(O)C=C(O)C4)C5=CC(OC)=C(O)C=C5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.0728 mL	10.3640 mL	20.7280 mL
5 mM	0.4146 mL	2.0728 mL	4.1456 mL
10 mM	0.2073 mL	1.0364 mL	2.0728 mL
50 mM	0.0415 mL	0.2073 mL	0.4146 mL

Description

Isosilybin (Silymarin, Silybin B, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. Isosilybin inhibits induction with an IC50 of 74 μM.

Targets

CYP3A4 ^[1]
(Cell-free assay)

74 μM

References

[1] Kim D Mooiman, et al. Drug Metab Dispos . 2013 Aug;41(8):1494-504.

Synonyms

4H-1-Benzopyran-4-one, 2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-

1,4-Benzodioxin, 4H-1-benzopyran-4-one deriv.

(2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one

Isosilybin

Isosilybinin

Isosilibinin