[CAS NO. 1639208-54-0] Valbenazine tosylate
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PRODUCTS SPECIFICATIONS [1639208-54-0]
Catalog
SLK-S9500
Brand
Selleck
CAS
1639208-54-0
DESCRIPTION [1639208-54-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 762.97 |
| Molecular Formula | C38H54N2O10S2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3107 mL | 6.5533 mL | 13.1067 mL |
| 5 mM | 0.2621 mL | 1.3107 mL | 2.6213 mL |
| 10 mM | 0.1311 mL | 0.6553 mL | 1.3107 mL |
| 50 mM | 0.0262 mL | 0.1311 mL | 0.2621 mL |
Description
Valbenazine tosylate (NBI-98854) is the tosylate salt of valbenazine, a inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM).
Targets
| VMAT2 [1] |
| 150 nM(Ki) |
In vitro
Valbenazine is a potent, selective, and specific inhibitor of VMAT2 with no inhibition of the related VMAT1 transporter and minimal off-target interactions at more than 80 other receptor transporters and ion channels.
In vivo
Valbenazine is a novel and highly selective VMAT2 inhibitor that is rapidly absorbed but more slowly metabolized, with a half-life of approximately 20 h that supports once-daily dosing. Valbenazine has moderate absorption with an absolute oral bioavailability of approximately 49%; time to maximum concentration ranges from 0.5 to 1.0 hour. Valbenazine can be taken with or without food. Valbenazine exhibits protein binding of 99%. Valbenazine is primarily metabolized via the hydrolysis of the valine ester and cytochrome P450 (CYP) 3A4/5 into R,R,R-HTBZ and a mono-oxy metabolite.
References
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