[CAS NO. 300815-04-7] Apcin
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PRODUCTS SPECIFICATIONS [300815-04-7]
Catalog
SLK-S9605
Brand
Selleck
CAS
300815-04-7
DESCRIPTION [300815-04-7]
Overview
| MDL | MFCD00525727 |
|---|---|
| Molecular Weight | 438.65 |
| Molecular Formula | C13H14Cl3N7O4 |
| SMILES | O=C(OCCN1C([N+]([O-])=O)=CN=C1C)NC(NC2=NC=CC=N2)C(Cl)(Cl)Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2797 mL | 11.3986 mL | 22.7972 mL |
| 5 mM | 0.4559 mL | 2.2797 mL | 4.5594 mL |
| 10 mM | 0.2280 mL | 1.1399 mL | 2.2797 mL |
| 50 mM | 0.0456 mL | 0.2280 mL | 0.4559 mL |
Description
Apcin (APC inhibitor) is an inhibitor of the E3 ligase activity of the mitotic that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.
In vitro
Apcin is a novel cell‑permeable molecule that blocks the interaction between APC/C and Cdc20. Apcin is demonstrated to inhibit OS cell growth and induce significant apoptosis. The invasion and mobile abilities of OS cells are also markedly suppressed by apcin treatment. Furthermore, Bim and p21 are upregulated in OS cells following apcin treatment. The inhibition of CDC20 with its inhibitor Apcin reduces the adhesion rate and proliferation ability to RL95-2 and HEC-1A cells, respectively.
References
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