[CAS NO. 2113650-03-4] BMS-1001
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PRODUCTS SPECIFICATIONS [2113650-03-4]
Store
Catalog
SLK-S9610
Brand
Selleck
CAS
2113650-03-4
DESCRIPTION [2113650-03-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 594.65 |
| Molecular Formula | C35H34N2O7 |
| SMILES | CC1=CC(=C(C=C1OCC2=C(C(=CC=C2)C3=CC4=C(C=C3)OCCO4)C)OCC5=CC(=CC=C5)C#N)CNC(CO)C(=O)O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6817 mL | 8.4083 mL | 16.8166 mL |
| 5 mM | 0.3363 mL | 1.6817 mL | 3.3633 mL |
| 10 mM | 0.1682 mL | 0.8408 mL | 1.6817 mL |
| 50 mM | 0.0336 mL | 0.1682 mL | 0.3363 mL |
Description
BMS-1001 is a potent inhibitor of interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.
Targets
| PD-1/PD-L1 [1] (Cell-free assay) |
| 253 nM(EC50) |
In vitro
BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is effective in attenuating the inhibitory effect of the cell surface-associated PD-L1.
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