[CAS NO. 162640-98-4] AT-56

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PRODUCTS SPECIFICATIONS [162640-98-4]

Catalog

SLK-S9678

Brand

Selleck

CAS

162640-98-4

DESCRIPTION [162640-98-4]

Overview

MDL	MFCD18086874
Molecular Weight	397.52
Molecular Formula	C25H27N5
SMILES	N1(CCCCC2=NNN=N2)CC/C(CC1)=C3C4=CC=CC=C4C=CC5=CC=CC=C/35

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5156 mL	12.5780 mL	25.1560 mL
5 mM	0.5031 mL	2.5156 mL	5.0312 mL
10 mM	0.2516 mL	1.2578 mL	2.5156 mL
50 mM	0.0503 mL	0.2516 mL	0.5031 mL

Description

AT-56 is an orally active and selective inhibitor of with Ki of 75 μM and IC50 of 95 μM.

Targets

L-PGDS ^[1] (Cell-free assay)	L-PGDS ^[1] (Cell-free assay)
75 μM(Ki)	95 μM

In vitro

AT-56 inhibits human and mouse L-PGDSs in a concentration (3–250 μm)-dependent manner. AT-56 inhibits the L-PGDS activity in a competitive manner against the substrate PGH2 (Km = 14 μm) with a Ki value of 75 μm. AT-56 inhibits the production of PGD2 by L-PGDS-expressing human TE-671 cells after stimulation with Ca2+ ionophore (5 μm A23187) with an IC50 value of about 3 μm without affecting their production of PGE2 and PGF2α.

References

[1] Daisuke Irikura, et al. J Biol Chem. 2009 Mar 20;284(12):7623-30.