[CAS NO. 172922-91-7] FICZ

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PRODUCTS SPECIFICATIONS [172922-91-7]

Catalog

SLK-S9682

Brand

Selleck

CAS

172922-91-7

DESCRIPTION [172922-91-7]

Overview

MDL	MFCD09879259
Molecular Weight	284.31
Molecular Formula	C19H12N2O
SMILES	C(=O)C1=C2C(=CC3=C1NC=4C3=CC=CC4)NC=5C2=CC=CC5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

FICZ (6-Formylindolo[3,2-b]carbazole) is a potent agonist of that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes.

Targets

AhR ^[1]

In vitro

In vitro studies in cells show that CYP1 inhibition in the presence of FICZ results in enhanced AHR activation, suggesting that FICZ accumulates in the cell when its metabolism is blocked. FICZ significantly upregulates the gene expression of filaggrin in both HaCaT cells and NHEKs in an AHR-dependent manner, but does not affect the gene expression of other barrier-related proteins.

References

[1] Emma Wincent, et al. Biochem Pharmacol. 2016 Jun 15;110-111:117-29.
[2] Mari Kiyomatsu-Oda, et al. J Dermatol Sci. 2018 Jun;90(3):284-294.

Synonyms

Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-

5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde

6-Formylindolo[3,2-b]carbazole

FICZ