[CAS NO. 2088410-46-0] GSK620
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PRODUCTS SPECIFICATIONS [2088410-46-0]
Store
Catalog
SLK-S9685
Brand
Selleck
CAS
2088410-46-0
DESCRIPTION [2088410-46-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 325.36 |
| Molecular Formula | C18H19N3O3 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0735 mL | 15.3676 mL | 30.7352 mL |
| 5 mM | 0.6147 mL | 3.0735 mL | 6.1470 mL |
| 10 mM | 0.3074 mL | 1.5368 mL | 3.0735 mL |
| 50 mM | 0.0615 mL | 0.3074 mL | 0.6147 mL |
Description
GSK620 is a pan- inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.
Targets
| BD2 [1] |
In vitro
GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 is capable of reducing the MCP-1 response in a concentration-dependent manner, providing strong evidence that GSK620 is indeed engaging BD2 in cells.
References
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