[CAS NO. 105925-39-1] iHAP1
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PRODUCTS SPECIFICATIONS [105925-39-1]
Catalog
SLK-S9695
Brand
Selleck
CAS
105925-39-1
DESCRIPTION [105925-39-1]
Overview
| MDL | MFCD01245092 |
|---|---|
| Molecular Weight | 367.85 |
| Molecular Formula | C20H14ClNO2S |
| SMILES | O=C(N1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13)C4=CC=C(OC)C=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7185 mL | 13.5925 mL | 27.1850 mL |
| 5 mM | 0.5437 mL | 2.7185 mL | 5.4370 mL |
| 10 mM | 0.2718 mL | 1.3592 mL | 2.7185 mL |
| 50 mM | 0.0544 mL | 0.2718 mL | 0.5437 mL |
Description
iHAP1 is a well-established microtubule poison, blocks fully at 5 µM which is independent of deregulated transcription, causes marked sensitization when deleting Rod1 gene in HeLa cells.
Targets
| microtubule polymerization [1] |
In vitro
The depletion of Rod1 and TACC3 results in sensitization to iHAP1, which is caused by chemogenic interaction between Rod1 and iHAP1. As for the RPE1‐hTERT P53−/− background, deletion of Rod1 in HeLa cells causes marked sensitization to iHAP1.
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