[CAS NO. 222716-34-9] SZL P1-41
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PRODUCTS SPECIFICATIONS [222716-34-9]
Catalog
SLK-S9724
Brand
Selleck
CAS
222716-34-9
DESCRIPTION [222716-34-9]
Overview
| MDL | MFCD00711481 |
|---|---|
| Molecular Weight | 420.52 |
| Molecular Formula | C24H24N2O3S |
| SMILES | O=C1C(C2=NC3=CC=CC=C3S2)=COC4=C1C=C(CC)C(O)=C4CN5CCCCC5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3780 mL | 11.8900 mL | 23.7801 mL |
| 5 mM | 0.4756 mL | 2.3780 mL | 4.7560 mL |
| 10 mM | 0.2378 mL | 1.1890 mL | 2.3780 mL |
| 50 mM | - | - | - |
Description
SZL P1-41 (compound #25) is a specific inhibitor of that indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells. SZL P1-41 causes higher rates in cancer cells.
Targets
| Skp2 [1] |
In vitro
SZL P1-41 indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells.
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