[CAS NO. 896657-58-2] MGH-CP1
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PRODUCTS SPECIFICATIONS [896657-58-2]
Catalog
SLK-S9735
Brand
Selleck
CAS
896657-58-2
DESCRIPTION [896657-58-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 368.50 |
| Molecular Formula | C20H24N4OS |
| SMILES | O=C(NC1=CC=C(C23CC4CC(C3)CC(C4)C2)C=C1)CSC5=NC=NN5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7137 mL | 13.5685 mL | 27.1370 mL |
| 5 mM | 0.5427 mL | 2.7137 mL | 5.4274 mL |
| 10 mM | 0.2714 mL | 1.3569 mL | 2.7137 mL |
| 50 mM | 0.0543 mL | 0.2714 mL | 0.5427 mL |
Description
MGH-CP1 is a potent and selective inhibitor of . MGH-CP1 exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively.
In vitro
MGH-CP1 exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro. MGH-CP1 treatment markedly decreases the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 does not affect auto-palmitoylation of several ZDHHC-family palmitoyl acyltransferases, suggesting its selectivity toward TEADs. MGH-CP1 is a selective small-molecule pan-TEAD inhibitor by directly targeting TEAD auto-palmitoylation.
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