[CAS NO. 165668-41-7] Indisulam
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PRODUCTS SPECIFICATIONS [165668-41-7]
Store
Catalog
SLK-S9742
Brand
Selleck
CAS
165668-41-7
DESCRIPTION [165668-41-7]
Overview
| MDL | MFCD00945325 |
|---|---|
| Molecular Weight | 385.85 |
| Molecular Formula | C14H12ClN3O4S2 |
| SMILES | N(S(=O)(=O)C1=CC=C(S(N)(=O)=O)C=C1)C2=C3C(C(Cl)=CN3)=CC=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Indisulam (E7070), a sulfonamide anticancer agent, is a potent inhibitor that inhibits and , and transmembrane, tumor-associated . Indisulam suppresses the expression of and phosphorylation of , both of which are essential for the G1 to S transition.
In vitro
Following treatment with E7070, the cell cycle progression of P388 murine leukaemia cells is disturbed in the G1 phase. The cell-killing effect on human colon cancer HCT116 cells is found to be time-dependent. In the panel of 42 human tumour cell lines, E7070 shows an antitumour spectrum that is distinct from those of other anticancer drugs used in clinic.
References
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