[CAS NO. 1370554-01-0] Ciliobrevin D
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PRODUCTS SPECIFICATIONS [1370554-01-0]
Catalog
SLK-S9743
Brand
Selleck
CAS
1370554-01-0
DESCRIPTION [1370554-01-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 392.62 |
| Molecular Formula | C17H8Cl3N3O2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5470 mL | 12.7350 mL | 25.4699 mL |
| 5 mM | 0.5094 mL | 2.5470 mL | 5.0940 mL |
| 10 mM | 0.2547 mL | 1.2735 mL | 2.5470 mL |
| 50 mM | 0.0509 mL | 0.2547 mL | 0.5094 mL |
Description
Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motor . Ciliobrevin D perturbs primary cilia formation and blocks signaling.
In vitro
Ciliobrevin D inactivate dynein in Sertoli cells. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the Sertoli cells in vitro. Ciliobrevin D perturbs protein trafficking within the primary cilium, leading to their malformation and Hedgehog signaling blockade. Ciliobrevin D also prevents spindle pole focusing, kinetochore-microtubule attachment, melanosome aggregation, and peroxisome motility in cultured cells.
References
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