[CAS NO. 897326-30-6] DTHIB
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PRODUCTS SPECIFICATIONS [897326-30-6]
Catalog
SLK-S9806
Brand
Selleck
CAS
897326-30-6
DESCRIPTION [897326-30-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 309.68 |
| Molecular Formula | C13H9ClFN3O3 |
| SMILES | O=C(NC1=CC=C(F)C=C1)NC2=CC=C(Cl)C([N+]([O-])=O)=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2291 mL | 16.1457 mL | 32.2914 mL |
| 5 mM | 0.6458 mL | 3.2291 mL | 6.4583 mL |
| 10 mM | 0.3229 mL | 1.6146 mL | 3.2291 mL |
| 50 mM | 0.0646 mL | 0.3229 mL | 0.6458 mL |
Description
DTHIB (Direct Targeted HSF1 InhiBitor) is a direct and selective inhibitor of with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities.
Targets
| HSF1 [1] (Cell-free assay) |
| 160 nM(Kd) |
In vitro
Direct Targeted HSF1 InhiBitor (DTHIB) physically engages HSF1 and selectively stimulates degradation of nuclear HSF1. DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
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