[CAS NO. 2376255-48-8] Ac-FLTD-CMK

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [2376255-48-8]

Catalog

SLK-S9817

Brand

Selleck

CAS

2376255-48-8

DESCRIPTION [2376255-48-8]

Overview

MDL	-
Molecular Weight	569.05
Molecular Formula	C26H37ClN4O8
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.7573 mL	8.7866 mL	17.5731 mL
5 mM	0.3515 mL	1.7573 mL	3.5146 mL
10 mM	0.1757 mL	0.8787 mL	1.7573 mL
50 mM	0.0351 mL	0.1757 mL	0.3515 mL

Description

Ac-FLTD-CMK is a specific inhibitor for inflammatory . Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.

Targets

caspases-1 ^[1] (Cell-free assay)	caspases-5 ^[1] (Cell-free assay)	caspases-4 ^[1] (Cell-free assay)
46.7 nM	329 nM	1.49 μM

In vitro

A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage in vitro and suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes.

References

[1] Jie Yang, et al. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797.
[2] Pengfei Wang, et al. Neuroreport. 2021 Feb 3;32(3):188-197.