[CAS NO. 218137-86-1] C75

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PRODUCTS SPECIFICATIONS [218137-86-1]

Catalog

SLK-S9819

Brand

Selleck

CAS

218137-86-1

DESCRIPTION [218137-86-1]

Overview

MDL	-
Molecular Weight	254.32
Molecular Formula	C14H22O4
SMILES	C(CCCCCCC)C1C(C(O)=O)C(=C)C(=O)O1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.9321 mL	19.6603 mL	39.3205 mL
5 mM	0.7864 mL	3.9321 mL	7.8641 mL
10 mM	0.3932 mL	1.9660 mL	3.9321 mL
50 mM	0.0786 mL	0.3932 mL	0.7864 mL

Description

C75 (4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid) , a more stable synthetic mimic of cerulenin, inhibits with an IC50 of 15.53 μM and has potential therapeutic effects in several cancer models. C75 is also a potent CPT1A activator.

Targets

FAS/FASN ^[1]

15.53 μM

In vitro

C75, the competitive irreversible fatty acid synthase (FASN) inhibitor, possesses radiosensitizing activity in prostate cancer cell lines that is affected by the availability of fatty acids, also increases expression of fatty acid transporter proteins FATP1 and CD36.

References

[1] Wang X,et al. Bioorg Med Chem. 2009 Mar 1;17(5):1898-904.
[2] Cheng X, et al. Org Lett. 2014 Mar 7;16(5):1414-7.
[3] Rae C, et al. Adv Radiat Oncol. 2020 Jun 29;5(5):994-1005.
[4] Thupari JN, et al. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

Synonyms

3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-

Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid

C 75

C 75 (enzyme inhibitor)

4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid