[CAS NO. 84-36-6] Syrosingopine (Su-3118)

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PRODUCTS SPECIFICATIONS [84-36-6]

Catalog

SLK-S9907

Brand

Selleck

CAS

84-36-6

DESCRIPTION [84-36-6]

Overview

MDL	MFCD00017411
Molecular Weight	666.71
Molecular Formula	C35H42N2O11
SMILES	C(OC)(=O)[C@H]1[C@]2(C[C@@]3(C4=C(C=5C(N4)=CC(OC)=CC5)CCN3C[C@]2(C[C@@H](OC(=O)C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)[C@@H]1OC)[H])[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.4999 mL	7.4995 mL	14.9990 mL
5 mM	0.3000 mL	1.4999 mL	2.9998 mL
10 mM	0.1500 mL	0.7500 mL	1.4999 mL
50 mM	0.0300 mL	0.1500 mL	0.3000 mL

Description

Syrosingopine (Su-3118) is a dual and inhibitor with IC50 values of 2500nM and 40 nM in HAP1 cells, respectively.

Targets

MCT4 ^[1] (in HAP1 cell)	MCT1 ^[1] (in HAP1 cell)
40 nM	2500 nM

In vitro

Syrosingopine treatment leads to high intracellular lactate levels and thereby end-product inhibition of lactate dehydrogenase by inhibiting the Lactate Transporters MCT1 and MCT4. The loss of NAD+ regeneration capacity due to combined metformin and syrosingopine treatment results in glycolytic blockade, leading to ATP depletion and cell death. ^[1]

References

[1] Don Benjamin, et al. Cell Rep. 2018 Dec 11;25(11):3047-3058.e4.

Synonyms

Yohimban-16-carboxylic acid, 18-[[4-[(ethoxycarbonyl)oxy]-3,5-dimethoxybenzoyl]oxy]-11,17-dimethoxy-, methyl ester, (3β,16β,17α,18β,20α)-

3β,20α-Yohimban-16β-carboxylic acid, 18β-hydroxy-11,17α-dimethoxy-, methyl ester, 4-hydroxy-3,5-dimethoxybenzoate (ester) ethyl carbonate (ester)

Reserpic acid, methyl ester, ester with syringic acid, ethyl carbonate

Carbethoxysyringoyl methylreserpate

Methyl carbethoxysyringoyl reserpate

Methyl reserpate ester of syringic acid ethyl carbonate

Singoserp

Syringic acid ethyl carbonate ester with methyl reserpate

Syrosingopine

Su 3118

Isotense

Syrosingopin

Syringopine

Siringina

Seniramin

Londomin

Raunova

NSC 77030

SML 1908