[CAS NO. 338404-52-7] CITCO

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PRODUCTS SPECIFICATIONS [338404-52-7]

Catalog

SLK-S9914

Brand

Selleck

CAS

338404-52-7

DESCRIPTION [338404-52-7]

Overview

MDL	MFCD00139608
Molecular Weight	436.74
Molecular Formula	C19H12Cl3N3OS
SMILES	C(=NOCC1=CC(Cl)=C(Cl)C=C1)C2=C(N=C3N2C=CS3)C4=CC=C(Cl)C=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2897 mL	11.4485 mL	22.8969 mL
5 mM	0.4579 mL	2.2897 mL	4.5794 mL
10 mM	0.2290 mL	1.1448 mL	2.2897 mL
50 mM	0.0458 mL	0.2290 mL	0.4579 mL

Targets

CAR ^[1]
(in CAR/SRC-1 FRET assay)

49 nM(EC50)

In vitro

CITCO (1-50 μM; 48 hours) results in a dose-dependent inhibition of viable cell count and proliferation in both T98G and U87MG glioma and BTSCs. CITCO (2.5, 5 μM; 48 hours) induces cell cycle arrest differentially in different BTSCs in culture, but not in normal astrocytes. CITCO (2.5-10 μM; 48 hours) induces apoptosis in BTSCs in culture in dose dependently, but not in normal astrocytes. CITCO (0-25 μM; 48 hours) causes the T98G and U87MG glioma and BTSCs expressing very low levels of CAR protein.^[2]

References

[1] Jodi M Maglich, et al.J Biol Chem. 2003 May 9;278(19):17277-83.
[2] Chakraborty S, et al. Br J Cancer. 2011 Feb 1;104(3):448-59.

Synonyms

Imidazo[2,1-b]thiazole-5-carboxaldehyde, 6-(4-chlorophenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime

6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carboxaldehyde O-[(3,4-dichlorophenyl)methyl]oxime

CITCO

6-(4-Chlorophenyl)imidazo-[2,1-b]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime