[CAS NO. 2230186-18-0] VB124

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PRODUCTS SPECIFICATIONS [2230186-18-0]

Catalog

SLK-S9929

Brand

Selleck

CAS

2230186-18-0

DESCRIPTION [2230186-18-0]

Overview

MDL	-
Molecular Weight	426.89
Molecular Formula	C23H23ClN2O4
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

VB124, a potent and selective inhibitor, specifically inhibits in MDA-MB-231 cells expressing MCT4, and is used for the research of cardiac hypertrophy, heart failure, and metabolism.

Targets

MCT4 ^[1] (in the MCT4 fluorescence-based activity assays)	MCT4 ^[1] (in the MCT4 fluorescence-based activity assays)
8.6 nM	19 nM

In vitro

VB124 is a potent and selective MCT4 inhibitor that specifically inhibits lactate efflux and redirects glycolytic carbon flux into mitochondrial pyruvate oxidation.

References

[1] Cluntun AA, et al. Cell Metab. 2021;33(3):629-648.e10.
[2] Cluntun AA, et al. Cell Metab. 2021 Mar 2;33(3):629-648.e10.