ChemScene

Tired of the limitations of traditional benzene rings in drug design? Bicyclo[2.2.2]octane (BCO), a saturated 3D bridged bicyclic scaffold, is here to change the game as a top-tier benzene bioisostere in medicinal chemistry. Its rigid, sp³-rich structure builds a compact, stable cage-like framework that’s perfectly built for modern drug development.

The 2026 ASCO Annual Meeting witnessed a real highlight: Daraxonrasib, a pan-RAS non-degrading molecular glue from Revolution Medicines, stole the show. Its presentation ended with a standing ovation from all attending experts!

Breakthrough on Silane-mediated Polymer Bonding Published in Nature Communications Body